CovidChloroV1, Main, Exploration, bibRecord, 000992

Very severe COVID-19 in the critically ill in Tunisia.

Identifieur interne : 000992 ( Main/Exploration ); précédent : 000991; suivant : 000993

Very severe COVID-19 in the critically ill in Tunisia.

Auteurs : Imen Ben Saida [Tunisie] ; Emna Ennouri [Tunisie] ; Rayane Nachi [Tunisie] ; Khaoula Meddeb [Tunisie] ; Jihene Mahmoud [Tunisie] ; Nesrine Thabet [Tunisie] ; Salma Jerbi [Tunisie] ; Mohamed Boussarsar [Tunisie]

Source :

The Pan African medical journal [ 1937-8688 ] ; 2020.

RBID : pubmed:33193951

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Antiviraux (usage thérapeutique), Betacoronavirus (MeSH), Comorbidité (MeSH), Diabète (épidémiologie), Délire avec confusion (étiologie), Femelle (MeSH), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Hôpitaux d'enseignement (statistiques et données numériques), Indice de gravité simplifié (MeSH), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (épidémiologie), Insuffisance rénale chronique (épidémiologie), Maladie grave (épidémiologie), Maladies cardiovasculaires (épidémiologie), Mortalité hospitalière (MeSH), Mâle (MeSH), Obésité (épidémiologie), Pandémies (MeSH), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (épidémiologie), Pronostic (MeSH), Tunisie (épidémiologie), Ventilation artificielle (statistiques et données numériques), Études rétrospectives (MeSH).
MESH :
- statistiques et données numériques : Hôpitaux d'enseignement, Ventilation artificielle.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antiviraux, Hydroxychloroquine.
- épidémiologie : Diabète, Infections à coronavirus, Insuffisance rénale chronique, Maladie grave, Maladies cardiovasculaires, Obésité, Pneumopathie virale, Tunisie.
- étiologie : Délire avec confusion.
- Adulte d'âge moyen, Betacoronavirus, Comorbidité, Femelle, Humains, Indice de gravité simplifié, Mortalité hospitalière, Mâle, Pandémies, Pronostic, Études rétrospectives.
Wicri :
- geographic : Tunisie.

English descriptors

KwdEn :
- Antiviral Agents (therapeutic use), Betacoronavirus (MeSH), COVID-19 (MeSH), Cardiovascular Diseases (epidemiology), Comorbidity (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Critical Illness (epidemiology), Delirium (etiology), Diabetes Mellitus (epidemiology), Female (MeSH), Hospital Mortality (MeSH), Hospitals, Teaching (statistics & numerical data), Humans (MeSH), Hydroxychloroquine (therapeutic use), Male (MeSH), Middle Aged (MeSH), Obesity (epidemiology), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology), Prognosis (MeSH), Renal Insufficiency, Chronic (epidemiology), Respiration, Artificial (statistics & numerical data), Respiratory Distress Syndrome (etiology), Retrospective Studies (MeSH), SARS-CoV-2 (MeSH), Simplified Acute Physiology Score (MeSH), Tunisia (epidemiology).
MESH :
- chemical , therapeutic use : Antiviral Agents, Hydroxychloroquine.
- geographic , epidemiology : Tunisia.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Cardiovascular Diseases, Coronavirus Infections, Critical Illness, Diabetes Mellitus, Obesity, Pneumonia, Viral, Renal Insufficiency, Chronic.
- etiology : Delirium, Respiratory Distress Syndrome.
- statistics & numerical data : Hospitals, Teaching, Respiration, Artificial.
- Betacoronavirus, COVID-19, Comorbidity, Female, Hospital Mortality, Humans, Male, Middle Aged, Pandemics, Prognosis, Retrospective Studies, SARS-CoV-2, Simplified Acute Physiology Score.

Abstract

Introduction

SARS-CoV-2 is an emerging health threat outbreak. It may cause severe viral pneumonia with Acute Respiratory Distress Syndrome requiring critical care. Aim: to describe clinical features and outcomes of critically ill patients with SARS-CoV-2 infection.

Methods

it was a retrospective study carried out in the medical ICU of Farhat Hached teaching hospital between March 11 and May 7, 2020. All consecutive patients with RT-PCR confirmed COVID-19 were included. Clinical characteristics and outcomes were collected by reviewing medical records.

Results

during the study period, 10 critically ill patients with COVID-19 were enrolled. Mean age, 51.8±6.3 years; 8(80%), male. The most common comorbidities were; diabetes mellitus, 6(60%), obesity 2(20%), chronic kidney disease 2(20%) and hypertension 1(10%). Mean SAPS II, 23.2±1.8. The mean arterial oxygen partial pressure to fractional inspired oxygen ratio at admission was 136.2±79.7. Noninvasive mechanical ventilation was used in 4(40%) patients and 7(70%) received invasive mechanical ventilation. Tidal volume and PEEP were set respectively within the median [IQR] of, 5.7[5.6-6.3]ml/Kg and 10.7[6.5-11.7]cm H

Conclusion

this study demonstrated a particular profile of COVID-19 in the critically ill as a severe presentation in aged males with comorbidities presenting with an ARDS-like and neurological impairment with poor prognosis. The only survivals seem to have benefited from noninvasive ventilatory support.

DOI: 10.11604/pamj.supp.2020.35.136.24753
PubMed: 33193951
PubMed Central: PMC7608765

Affiliations:

Tunisie

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000830
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Le document en format XML

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<term>Maladies cardiovasculaires</term>
<term>Obésité</term>
<term>Pneumopathie virale</term>
<term>Tunisie</term>
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<term>COVID-19</term>
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<front><div type="abstract" xml:lang="en"><p><b>Introduction</b>
</p>
<p>SARS-CoV-2 is an emerging health threat outbreak. It may cause severe viral pneumonia with Acute Respiratory Distress Syndrome requiring critical care. Aim: to describe clinical features and outcomes of critically ill patients with SARS-CoV-2 infection.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Methods</b>
</p>
<p>it was a retrospective study carried out in the medical ICU of Farhat Hached teaching hospital between March 11 and May 7, 2020. All consecutive patients with RT-PCR confirmed COVID-19 were included. Clinical characteristics and outcomes were collected by reviewing medical records.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Results</b>
</p>
<p>during the study period, 10 critically ill patients with COVID-19 were enrolled. Mean age, 51.8±6.3 years; 8(80%), male. The most common comorbidities were; diabetes mellitus, 6(60%), obesity 2(20%), chronic kidney disease 2(20%) and hypertension 1(10%). Mean SAPS II, 23.2±1.8. The mean arterial oxygen partial pressure to fractional inspired oxygen ratio at admission was 136.2±79.7. Noninvasive mechanical ventilation was used in 4(40%) patients and 7(70%) received invasive mechanical ventilation. Tidal volume and PEEP were set respectively within the median [IQR] of, 5.7[5.6-6.3]ml/Kg and 10.7[6.5-11.7]cm H</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Conclusion</b>
</p>
<p>this study demonstrated a particular profile of COVID-19 in the critically ill as a severe presentation in aged males with comorbidities presenting with an ARDS-like and neurological impairment with poor prognosis. The only survivals seem to have benefited from noninvasive ventilatory support.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>11</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1937-8688</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>35</Volume>
<Issue>Suppl 2</Issue>
<PubDate><Year>2020</Year>
</PubDate>
</JournalIssue>
<Title>The Pan African medical journal</Title>
<ISOAbbreviation>Pan Afr Med J</ISOAbbreviation>
</Journal>
<ArticleTitle>Very severe COVID-19 in the critically ill in Tunisia.</ArticleTitle>
<Pagination><MedlinePgn>136</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.11604/pamj.supp.2020.35.136.24753</ELocationID>
<Abstract><AbstractText Label="Introduction" NlmCategory="UNASSIGNED">SARS-CoV-2 is an emerging health threat outbreak. It may cause severe viral pneumonia with Acute Respiratory Distress Syndrome requiring critical care. Aim: to describe clinical features and outcomes of critically ill patients with SARS-CoV-2 infection.</AbstractText>
<AbstractText Label="Methods" NlmCategory="UNASSIGNED">it was a retrospective study carried out in the medical ICU of Farhat Hached teaching hospital between March 11 and May 7, 2020. All consecutive patients with RT-PCR confirmed COVID-19 were included. Clinical characteristics and outcomes were collected by reviewing medical records.</AbstractText>
<AbstractText Label="Results" NlmCategory="UNASSIGNED">during the study period, 10 critically ill patients with COVID-19 were enrolled. Mean age, 51.8±6.3 years; 8(80%), male. The most common comorbidities were; diabetes mellitus, 6(60%), obesity 2(20%), chronic kidney disease 2(20%) and hypertension 1(10%). Mean SAPS II, 23.2±1.8. The mean arterial oxygen partial pressure to fractional inspired oxygen ratio at admission was 136.2±79.7. Noninvasive mechanical ventilation was used in 4(40%) patients and 7(70%) received invasive mechanical ventilation. Tidal volume and PEEP were set respectively within the median [IQR] of, 5.7[5.6-6.3]ml/Kg and 10.7[6.5-11.7]cm H<sub>2</sub>
O. Plateau pressure was monitored in the median [IQR] of 27.9 [25.9-28.5] cm H<sub>2</sub>
O. Four patients received hydroxychloroquine alone and five hydroxychloroquine associated with an antiviral. Five patients developed respectively hyperactive (n=2), hypoactive (n=2) and mixed delirium (n=1). Mortality rate was at 70%.</AbstractText>
<AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">this study demonstrated a particular profile of COVID-19 in the critically ill as a severe presentation in aged males with comorbidities presenting with an ARDS-like and neurological impairment with poor prognosis. The only survivals seem to have benefited from noninvasive ventilatory support.</AbstractText>
<CopyrightInformation>Copyright: Imen Ben Saida et al.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Saida</LastName>
<ForeName>Imen Ben</ForeName>
<Initials>IB</Initials>
<AffiliationInfo><Affiliation>Medical Intensive Care Unit, Farhat Hached University Hospital, Faculty of medicine, University of Sousse, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Research Laboratory N° LR12SP09, Heart Failure, Farhat Hached University Hospital, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ennouri</LastName>
<ForeName>Emna</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Medical Intensive Care Unit, Farhat Hached University Hospital, Faculty of medicine, University of Sousse, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nachi</LastName>
<ForeName>Rayane</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Medical Intensive Care Unit, Farhat Hached University Hospital, Faculty of medicine, University of Sousse, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meddeb</LastName>
<ForeName>Khaoula</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Medical Intensive Care Unit, Farhat Hached University Hospital, Faculty of medicine, University of Sousse, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Research Laboratory N° LR12SP09, Heart Failure, Farhat Hached University Hospital, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mahmoud</LastName>
<ForeName>Jihene</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Medical Intensive Care Unit, Farhat Hached University Hospital, Faculty of medicine, University of Sousse, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thabet</LastName>
<ForeName>Nesrine</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Medical Intensive Care Unit, Farhat Hached University Hospital, Faculty of medicine, University of Sousse, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jerbi</LastName>
<ForeName>Salma</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Medical Intensive Care Unit, Farhat Hached University Hospital, Faculty of medicine, University of Sousse, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Boussarsar</LastName>
<ForeName>Mohamed</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Medical Intensive Care Unit, Farhat Hached University Hospital, Faculty of medicine, University of Sousse, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Research Laboratory N° LR12SP09, Heart Failure, Farhat Hached University Hospital, 4000, Sousse, Tunisia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Uganda</Country>
<MedlineTA>Pan Afr Med J</MedlineTA>
<NlmUniqueID>101517926</NlmUniqueID>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber>
<NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003693" MajorTopicYN="N">Delirium</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003920" MajorTopicYN="N">Diabetes Mellitus</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006784" MajorTopicYN="N">Hospitals, Teaching</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009765" MajorTopicYN="N">Obesity</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051436" MajorTopicYN="N">Renal Insufficiency, Chronic</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000072878" MajorTopicYN="N">Simplified Acute Physiology Score</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014416" MajorTopicYN="N" Type="Geographic">Tunisia</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">acute respiratory distress syndrome</Keyword>
<Keyword MajorTopicYN="N">pneumonia</Keyword>
</KeywordList>
<CoiStatement>The authors declare no competing interests.</CoiStatement>
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<tree><country name="Tunisie"><noRegion><name sortKey="Saida, Imen Ben" sort="Saida, Imen Ben" uniqKey="Saida I" first="Imen Ben" last="Saida">Imen Ben Saida</name>
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<name sortKey="Boussarsar, Mohamed" sort="Boussarsar, Mohamed" uniqKey="Boussarsar M" first="Mohamed" last="Boussarsar">Mohamed Boussarsar</name>
<name sortKey="Boussarsar, Mohamed" sort="Boussarsar, Mohamed" uniqKey="Boussarsar M" first="Mohamed" last="Boussarsar">Mohamed Boussarsar</name>
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<name sortKey="Jerbi, Salma" sort="Jerbi, Salma" uniqKey="Jerbi S" first="Salma" last="Jerbi">Salma Jerbi</name>
<name sortKey="Mahmoud, Jihene" sort="Mahmoud, Jihene" uniqKey="Mahmoud J" first="Jihene" last="Mahmoud">Jihene Mahmoud</name>
<name sortKey="Meddeb, Khaoula" sort="Meddeb, Khaoula" uniqKey="Meddeb K" first="Khaoula" last="Meddeb">Khaoula Meddeb</name>
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	Serveur d'exploration COVID et hydrochloroquine
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Very severe COVID-19 in the critically ill in Tunisia.

Very severe COVID-19 in the critically ill in Tunisia.

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